NanoparticlesLatest meeting between NANOSOLUTIONS and NanoMile

The latest in a series of high-level meetings between the NanoMILE and NanoSolutions projects is due to take place in Stockholm on September 13-14, 2016. The series of consensus meetings about nanosafety science has been considering alternative test methods for assessing the risk potential of nano particles being used in ever more everyday products. The alternative methods being discussed centre on high-throughput and “omics” approaches to nanosafety assessment.

 

The meeting in Stockholm in Spetember will discuss the data and methods exchange between NANOSOLUTIONS and NanoMILE. The aim is also to discuss the current status of the two alternative methods in nanosafety assessment, with the goal of exchanging ideas, opinions and experiences in order to reach consensus on the following

  1. terminology
  2. an agreed understanding of the current limitation of the approaches for different classes of nanomaterials;
  3. specific aspects of the workflows / protocols that need to be adjusted when handling nanomaterials compared to molecular chemicals, i.e. where the nano-aspects matter presented in a manner that is useful for regulators and decision makers.

As well as plenary sessions, there will also be breakout sessions, where groups will be structured around four separate discussion topics and each topic discussion will be led by members from the two projects, with summaries reported back in a plenary session with action items to be agreed. The four discussion topics are:

  1. Are nanomaterials dispersed appropriately over full exposure durations for HCA/omics?
  2. Potential interferences with read-outs from nanomaterials in HCA/omics – the scattering, binding, conformational changes
  3. Can these methods be applied to all nanomaterial types and classes? What limitations, if any, exist? And where or how do nanomaterials differ from conventional chemicals?
  4. The current progress and requirements in data analysis, data integration and predictive modelling

The outputs from the meeting will form a clear plan for data/methods exchange and a joint summary paper capturing the terminology, workflow adjustments and applicability to different classes of nanomaterials will be produced.

Furthermore, a white paper will be drafted on the steps needed to translate high-content analysis and “omics” approaches into regulatory testing frameworks and the initial roadmap that will be needed to achieve this.
For further information please contact:

NanoMILE Project manager: Tom Carney, email: t.carney@bham.ac.uk

NanoSolutions Project Manager: Elina Drakvik, email: elina.drakvik@ttl.fi