IPL recently hosted the latest NANOSOLUTIONS dissemination committee meeting, at which committee members discussed the current work of different work packages, the NANOSOLUTIONS safety Classifier and plans by IPL to increase communications activity now that results are beginning to emerge from the project’s experiments.

At the core of this communication activity will be the NANOSOLUTIONS Classifier, the computational tool for identifying potentially hazardous Engineered Nano Materials (ENMs) that will be the end result of the NANOSOLUTIONS project. The aim of the Classifier is to speed up the process of identifying the hazard potential in ENMs and make testing new ENMs more affordable, too. The Classifier will use complex algorithms being developed using data from experiments being conducted by NANOSOLUTIONS partners, who are exposing living organisms to 31 ENMs. By identifying specific contact points, the tool will be able to predict potential harmful impacts, so when new ENMs are developed, industry will be able to accurately assess their potential without the need for lengthy, expensive testing.

During the meeting Manuel Correia, from the Technical University of Denmark, discussed the work being undertaken by WP3 (Materials) whose primary aim is to provide the materials for the project and to have them all characterised. This work is interesting as they are working with unstable particles that represent how nanoparticles behave in the real world. “We are dealing with difficult particles, yes, but it’s a challenge we undertook to be more realistic,” says Correia. By adopting this more difficult line of testing and once results are fed into the Classifier, more realistic predictions of potential hazard will be available as the ENMs will have been tested in multiple ways and in the state they can be found in in the real world.

Stephanie Hirn from LMU Munich discussed the work of WP8 (Disease Models, a collaboration between LMU, TNO and FIOH) who are working on a multipronged approach including looking at fate and biological effects of nanoparticles in the diseased macro- and microvasculature (LMU), the effect of ENM coating on allergic airway inflammation (FIOH) and using human 3D in vitro airway model (TNO).

Meanwhile, Audrey Gallud from the Karolinska Institute (KI) reported on the work WP10 is doing on the assessment of nanotoxicity of individual materials selected using in-vitro tests in which 31 nanomaterials will be tested. Results from both Stephanie and Audrey will be available in the next six months.

Also on the agenda at the meeting was the forthcoming Systems Biology in Nanosafety Research conference, which is taking place at the Nobel Forum, Karolinska Institute in Stockholm on the 9th and 10th of November. The event is the third Mini-Conference on Nanotoxicology to be co-hosted by NANOSOLUTIONS and will be chaired by Professor Bengt Fadeel and Professor Juha Kere. The aim of the two-day meeting is to provide an overview of state-of-the-art systems biology approaches being used in nanosafety research.

IPL finished the meeting by announcing progress of the most recent NANOSOLUTIONS dissemination developments, including the production of the new film, which involves interviews with key members of the coordination group. The film explains the importance of ensuring the safety of ENMs and how the NANOSOLUTIONS Classifier will ensure this safety and it will be launched at the next project partner meeting, taking place in Stockholm in November.

  • The dissemination committee meets every month and partners will be selected to present their developments and any news at each meeting.
  • For information about NANOSOLUTIONS dissemination, contact dissemination work package leader William Davis at wdavis@ipl.eu.com