The following papers were submitted for publications by partners:
• Ahluwalia, D. Boraschi, H.J. Byrne, B. Fadeel, P. Gehr, A.C. Gutleb, M. Kendall, M. Papadopoulos and I. Lynch. The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design. BioNanoMat 2013
• D. Carrella , F. Napolitano , R. Rispoli , M. Miglietta , A. Carissimo , L. Cutillo , F. Sirci , F. Gregoretti , D. Di Bernardo Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis. 10.1093/bioin formatics/btu058 Bioinformatics 2014
• Stefanie Grafmueller , Pius Manser , Liliane Diener , Pierre-André Diener , Xenia Maeder-Althau , Lionel Maurizi , Wolfram Jochum , Harald F. Krug , Tina Buerki-Thurnhe , Ursula von Mandach , Peter Wick Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model.10.1289/ehp.1 409271 B Environmental Health Perspectives 2015
• Michele Fratello, Angela Serra, Vittorio Fortino, Giancarlo Raiconi, Roberto Tagliaferri and Dario Greco. A multi-view genomic data simulator. BMC Bioinformatics 2015
• Angela Serra, Michele Fratello, Vittorio Fortino, Giancarlo Raiconi, Roberto Tagliaferri and Dario Greco. MVDA: a multi-view genomic data integration methodology. BMC Bioinformatics 2015
• Neus Feliu , Pekka Kohonen , Jie Ji , Yuning Zhang , Hanna L. Karlsson , Lena Palmberg , Andreas Nyström , Bengt Fadeel. Next-Generation Sequencing Reveals Low-Dose Effects of Cationic Dendrimers in Primary Human Bronchial Epithelial Cells 10.1021/nn506 1783. ACS Nano 2015
• Audrey Gallud , Bengt Fadeel. Keeping it small: towards a molecular definition of nanotoxicology 10.1515/ejnm- 2015-0020. European Journal of Nanomedicine 2015
• Bengt Fadeel. Systems biology in nanosafety research 10.2217/nnm.1 5.17. Nanomedicine 2015
• Carmen Vogt , Maria Pernemalm , Pekka Kohonen , Sophie Laurent , Kjell Hultenby , Marie Vahter , Janne Lehtiö , Muhammet S. Toprak , Bengt Fadeel. Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages 10.1371/journ al.pone.0129008. PLoS One 2015
• Sha Wan, Philip M. Kelly, Eugene Mahon, Henning Stockmann, Pauline M. Rudd, Frank Caruso, Kenneth A. Dawson, Yan Yan, and Marco P. Monopoli. The “sweet” side of the protein corona:Effects of glycosylation on nanoparticle-cell interactions 10.1021/nn506 060q. ACS Nano 2015
• D. J. O’Connell , F. Baldelli Bombelli , A. S. Pitek , M. P. Monopoli , D. J. Cahill , K. A. Dawson. Characterization of the bionano interface and mapping extrinsic interactions of the corona of nanomaterials 10.1039/c5nr0 1970b. Nanoscale 2015
• Philip M. Kelly , Christoffer Åberg , Ester Polo , Ann O’Connell , Jennifer Cookman , Jonathan Fallon , Željka Krpeti# , Kenneth A. Dawson. Mapping protein binding sites on the biomolecular corona of nanoparticles 10.1038/NNANO .2015.47. Nature Nanotechnology 2015
• Francesco Napolitano , Francesco Sirci , Diego Carrella , Diego di Bernardo. Drug-set enrichment analysis: a novel tool to investigate drug mode of action 10.1093/bioin formatics/btv536. Bioinformatics 2015
• Katharina Nekolla , Kerstin Kick , Sabine Sellner , Karina Mildner , Stefan Zahler , Dagmar Zeuschner , Fritz Krombach , Markus Rehberg. Nanoparticles: Influence of Surface Modifications on the Spatiotemporal Microdistribution of Quantum Dots In Vivo (Small 19/2016) 10.1002/smll. 201670100. Small 2016
• Steffen Dietzel , Stefanie Hermann , Yan Kugel , Sabine Sellner , Bernd Uhl , Stephanie Hirn , Fritz Krombach , Markus Rehberg. Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo 10.1002/smll. 201503766. Small 2016
• Leonhard Möckl , Stephanie Hirn , Adriano A Torrano , Bernd Uhl , Christoph Bräuchle , Fritz Krombach. The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro 10.2217/nnm-2 016-0332. Nanomedicine 2017
• Carina Muoth, Leonie Aengenheister , Melanie Kucki , Peter Wick , Tina Buerki-Thurnherr. Nanoparticle transport across the placental barrier: pushing the field forward! 10.2217/nnm-2 015-0012. Nanomedicine 2016
• Carina Muoth , Adrian Wichser , Marco Manuel Correia , Nicky Ehrlich , Katrin Loeschner , Audrey Gallud , Melanie Kucki , Liliane Diener , Pius Manser , Wolfram Jochum , Peter Wick , Tina Buerki-Thurnherr. A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment 10.1039/c6nr0 6749b. Nanoscale 2016
• C. Muoth , M. Rottmar , A. Schipanski ,C. Gmuender, K. Maniura-Weber, P. Wick , T. Buerki-Thurnherr. A micropatterning approach to study the influence of actin cytoskeletal organization on polystyrene nanoparticle uptake by BeWo cells 10.1039/C6RA137 82B. RSC Advances 2016.
• Bernd Uhl ,Stephanie Hirn , Roland Immler , Karina Leonhard Möckl , Markus Sperandio , Christoph Bräuchle , Christoph A. Reichel , Dagmar Zeuschner , Fritz Krombach. The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood–Tissue Border. 10.1021/acsna no.6b06812. ACS Nano 2017
• Pekka Kohonen , Rebecca Ceder , Ines Smit , Vesa Hongisto , Glenn Myatt , Barry Hardy , Ola Spjuth , Roland Grafström. Cancer Biology, Toxicology and Alternative Methods Development Go Hand-in-Hand 10.1111/bcpt. 12257. Basic and Clinical Pharmacology and Toxicology 2014
• Audrey Gallud , Olesja Bondarenko , Neus Feliu , Natalia Kupferschmidt , Rambabu Atluri , Alfonso Garcia-Bennett , Bengt Fadeel. Macrophage activation status determines the internalization of mesoporous silica particles of different sizes: Exploring the role of different pattern recognition receptors 10.1016/j.bio materials.2016.12.029. Biomaterials 2017
• Nataliya K. Tarasova , Audrey Gallud , A. Jimmy Ytterberg , Alexey Chernobrovkin , Jaime Ruiz Aranzaes , Didier Astruc , Alexei Antipov , Yuri Fedutik , Bengt Fadeel , Roman A.Zubarev. Cytotoxic and Proinflammatory Effects of Metal-Based Nanoparticles on THP-1 Monocytes Characterized by Combined Proteomics Approaches 10.1021/acs.j proteome.6b00747. Journal of Proteome Research 2017
• Carina Muoth, Mandy Großgarten, Uwe Karst, Jaime Ruiz, Didier Astruc, Sergio Moya, Liliane Diener, Kathrin Grieder, Adrian Wichser , Wolfram Jochum , Peter Wick , Tina Buerki-Thurnherr. Impact of particle size and surface modification on gold nanoparticle penetration into human placental microtissues. 10.2217/nnm-2 017-0428. Nanomedicine 2017.
• Lindberg, Ghita C.-M. Falck, Rajinder Singh, Satu Suhonen, Hilkka Järventaus, Esa Vanhala, Julia Catalán, Peter B. Farmer, Kai M. Savolainen, Hannu Norppa. Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro. 10.1016/j.tox .2012.12.008. Toxicology 2013.
• Bengt Fadeel, Harri Alenius, Kai Savolainen. Nanotoxicology. 10.1016/j.tox .2013.09.010. Toxicology 2013.
• Michael R. Shurin, Naveena Yanamala, Elena R. Kisin, Alexey V. Tkach, Galina V. Shurin, Ashley R. Murray, Howard D. Leonard, Jeffrey S. Reynolds, Dmirtiy W. Gutkin, Alexander Star, Bengt Fadeel, Kai Savolainen, Valerian E. Kagan, Anna A. Shvedova. Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma. 10.1021/nn406 454u. ACS Nano 2014.
• Marit Ilves, Jaana Palomäki, Minnamari Vippola, Maili Lehto, Kai Savolainen, Terhi Savinko, Harri Alenius. Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model. 10.1186/s1298 9-014-0038-4. Particle and Fibre Toxicology 2014.
• Autumn L. Menas , Naveena Yanamala , Mariana T. Farcas , Maria Russo , Sherri Friend , Philip M. Fournier , Alexander Star , Ivo Iavicoli , Galina V. Shurin , Ulla B. Vogel , Bengt Fadeel , Donald Beezhold , Elena R. Kisin , Anna A. Shvedova. Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: Cytotoxicity or inflammation? 10.1016/j.che mosphere.2016.12.105. Chemosphere 2017
• Surakshya Shrestha , Zhengwei Mao , Yuri Fedutik , Changyou Gao. Influence of titanium dioxide nanorods with different surface chemistry on the differentiation of rat bone marrow mesenchymal stem cells 10.1039/c6tb021 49b. Journal of Materials Chemistry B 2016
• Wenjing Zhang , Pengfei Jiang , Wei Chen , Botuo Zheng , Zhengwei Mao , Alexei Antipov , Manuel Correia , Erik H Larsen , Changyou Gao. Genotoxicity of Copper Oxide Nanoparticles with Different Surface Chemistry on Rat Bone Marrow Mesenchymal Stem Cells https://doi.o rg/10.1166/jnn.2016.11753. Journal of Nanoscience and Nanotechnology 2016
• Maria Cristina Lo Giudice , Luciana M.Herda , Ester Polo , Kenneth A. Dawson. In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry 10.1038/ncomm s13475. Nature Communications 2016
• Sha Wan , Gabriella Egri , Letizia Oddo , Barbara Cerroni , Lars Dähne , Gaio Paradossi , Anna Salvati , Iseult Lynch , Kenneth A. Dawson , Marco P. Monopoli. Biological in situ characterization of polymeric microbubble contrast agents 10.1016/j.bioce l.2016.03.004. International Journal of Biochemistry and Cell Biology 2016
• Filippo Bertoli , David Garry , Marco P. Monopoli , Anna Salvati , Kenneth A. Dawson. The Intracellular Destiny of the Protein Corona: A Study on its Cellular Internalization and Evolution 10.1021/acsna no.6b06411. ACS Nano 2016
• H.L. Karlsson, M.S. Toprak and B. Fadeel. Toxicity of Metal and Metal Oxide Nanoparticles. In: Handbook on the Toxicology of Metals (4th Edition, eds: B. Fowler, G. Nordberg, M.Nordberg. Elsevier 2014 [in press]
• Rydman E, Ilves M, Koivisto J, Kinaret P, Fortino V, Savinko T, Lehto M, Pulkkinen V, Vippola M, Hämeri K, Matikainen S, Wolff H, Savolainen K, Greco D, Alenius H. Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation. Part Fibre Toxicol, 2014;11:48.DOI: 10.1186/s12989-014-0048-2
• Fratello F, Serra A, Fortino V, Raiconi G, Tagliaferri R, Greco D. A multi-view genomic data simulator. BMC Bioinformatics (under revision).
• Fortino V, Alenius H, Greco D. BACA: bubble chArt to compare annotations. BMC Bioinformatics. 2015 Feb 5;16(1):37.
• Fortino V, Kinaret P, Fyhrquist N, Alenius H, Greco D. A robust and accurate method for feature selection and prioritization from multi-class OMICs data. 10.1371/journ al.pone.0107801. PLoS One. 2014 Sep 23;9(9):e107801.
• Fortino V, Smolander O-P, Auvinen P, Tagliaferri R, Greco D. Transcriptome dynamics-based operon prediction in prokaryotes. 10.1186/1471- 2105-15-145. BMC Bioinformatics 2014, 15:145.
• Palomäki J, Sund J, Vippola M, Kinaret P, Greco D, Savolainen K, Puustinen A, Alenius H. A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes. 10.3109/17435 390.2014.969346. 2015 Oct 17:1-10. [Epub ahead of print]
• Jukka Sund, Jaana Palomäki, Niina Ahonen, Kai Savolainen, Harri Alenius, Anne Puustinen. Phagocytosis of nano-sized titanium dioxide triggers changes in protein acetylation. 10.1016/j.jpr ot.2014.06.011. Journal of Proteomics 2014.
• Yann Grosse, Dana Loomis, Kathryn Z Guyton, Béatrice Lauby-Secretan, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim-Tallaa, Neela Guha, Chiara Scoccianti, Heidi Mattock, Kurt Straif. 10.1016/S1470 -2045(14)71109-X. Lancet Oncology, The 2014.
• Julia Catalán, Marit Ilves, Hilkka Järventaus, Kati-Susanna Hannukainen, Eero Kontturi, Esa Vanhala, Harri Alenius, Kai M Savolainen, Hannu Norppa. Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro. 10.1002/em.21 913. Environmental and Molecular Mutagenesis 2015.
• Julia Catalán, Kirsi M. Siivola, Penny Nymark, Hanna Lindberg, Satu Suhonen, Hilkka Järventaus, Antti J. Koivisto, Carlos Moreno, Esa Vanhala, Henrik Wolff, Kirsten I. Kling, Keld Alstrup Jensen, Kai Savolainen, Hannu Norppa. In vitro and in vivo genotoxic effects of straight versus tangled multi-walled carbon nanotubes. Nanotoxicology 2016.
• Irina Guseva Canu, Thomas F. Bateson, Veronique Bouvard, Maximilien Debia, Chantal Dion, Kai Savolainen, Il-Je Yu. Human exposure to carbon-based fibrous nanomaterials: A review. 10.1016/j.ijh eh.2015.12.005. International Journal of Hygiene and Environmental Health 2016.
• Julia Catalán, Elina Rydman, Kukka Aimonen, Kati-Susanna Hannukainen, Satu Suhonen, Esa Vanhala, Carlos Moreno, Valérie Meyer, Denilson da Silva Perez, Asko Sneck, Ulla Forsström, Casper Højgaard, Martin Willemoes, Jacob R. Winther, Ulla Vogel, Henrik Wolff, Harri Alenius, Kai M. Savolainen, Hannu Norppa. Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs 10.1093/mutag e/gew035. Mutagenesis 2017.
• Pia Kinaret, Veer Marwah, Vittorio Fortino, Marit Ilves, Henrik Wolff, Lasse Ruokolainen, Petri Auvinen, Kai Savolainen, Harri Alenius, Dario Greco. Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo. 10.1021/acsna no.6b08650. ACS Nano 2017.
• Pia Kinaret, Marit Ilves, Vittorio Fortino, Elina Rydman, Piia Karisola, Anna Lähde, Joonas Koivisto, Jorma Jokiniemi, Henrik Wolff, Kai Savolainen, Dario Greco, Harri Alenius. Inhalation and Oropharyngeal Aspiration Exposure to Rod-Like Carbon Nanotubes Induce Similar Airway Inflammation and Biological Responses in Mouse Lungs. 10.1021/acsna no.6b05652. ACS Nano 2017.
• Vittorio Fortino, Roberto Tagliaferri, Dario Greco. CONDOP: an R package for CONdition-Dependent Operon Predictions. 10.1093/bioin formatics/btw330. Bioinformatics 2016.
• Elina M. Rydman, Marit Ilves, Esa Vanhala, Minnamari Vippola, Maili Lehto, Pia A. S.Kinaret, Lea Pylkkänen, Mikko Happo, Maija-Riitta Hirvonen, Dario Greco, Kai Savolainen, Henrik Wolff, Harri Alenius. A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor. 10.1093/toxsc i/kfv112. Toxicological Sciences 2015.
• O’Connell DJ, Bombelli FB, Pitek AS, Monopoli MP, Cahill DJ, Dawson KA. Characterization of the bionano interface and mapping extrinsic interactions of the corona of nanomaterials. Nanoscale. 2015 Sep 21;7(37):15268-76. doi: 10.1039/c5nr01970b.
• Wan S, Kelly PM, Mahon E, Stöckmann H, Rudd PM, Caruso F, Dawson KA, Yan Y, Monopoli MP. The “sweet” side of the protein corona: effects of glycosylation on nanoparticle-cell interactions. ACS Nano. 2015 Feb 24;9(2):2157-66. doi: 10.1021/nn506060q. Epub 2015 Feb 12.
• Kelly PM, Åberg C, Polo E, O’Connell A, Cookman J, Fallon J, Krpetić Ž, Dawson KA. Mapping protein binding sites on the biomolecular corona of nanoparticles. Nat Nanotechnol. 2015 May;10(5):472-9. doi: 10.1038/nnano.2015.47. Epub 2015 Mar 30.
• Grafmueller S., Manser P., Diener L., Maurizi L., Diener PA., Hofmann H., Jochum W., Krug HF., Buerki-Thurnherr T., von Mandach U., Wick P. (2015). Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts. Sci. Technol. Adv. Mater. 16 (4) 044602
• Grafmueller S., Manser P., Diener L., Diener PA., Maeder-Althaus X., Maurizi L., Jochum W., Krug H.F., Buerki-Thurnherr T., von Mandach U., Wick P. (2015). Differential bidirectional transfer of polystyrene nanoparticles across the placental barrier reveals different transport kinetics.
Environ Health Persp., DOI: 10.1289/ehp.1409271
• Buist, H.E., Hischier, R., Westerhout, J.Brouwer, D.H. – Derivation of health effect factors for nanoparticles to be used in LCIA – NanoImpact – Accepted for publication after minor revisions – December 2017
• J. Vassallo , A. Besinis , R. Boden , R.D. Handy. Evaluation of the minimum inhibition con centration (MIC) assay for environmental assessment of nanomaterials 10.1016/j.tox let.2016.06.1934 – Toxicology Letters
• Alejandro Vílchez , Elisa bet Fernán dez-Rosas , David González-Gálvez, Socorro Vázquez-Campos. – Nanomaterials Release from Nano-Enabled Products 10.1007/698_2 015_409 – Indoor and Outdoor Nanoparticle’s. Determinants of Release and Exposure Scenarios – April 2016
• Savolainen K, Pietroiusti A – Esposure Assessment 10.1016/B978- 0-12-809199-9.00005-7 – Adverse Effects of Engineered Nanomaterial’s. Eds. Bengt Fadeel, Antonio Pietroiusti and Anna A. Shvedova – March 2017
• Savolainen K, Gulumian M- Nanotechnology – Fan AM, Khan ME and Alexeeff GV (eds.) Emerging research and implications for health and policy – Toxicology and Risk Assessment – March 2015
• Savolainen Kai – General Introduction – Vogel U, Savolainen K, Wu Q, van Tongeren M, Brouwer D, Berges M (eds.) Handbook of Nanosafety. Measurement, Exposure and Toxicology – January 2014
• Alenius H, Catalan J, Lindberg H, Norppa H, Palomäki J, Savolainen K – Nanomaterials and human health -Vogel U, Savolainen K, Wu Q, van Tongeren M, Brouwer D, Berges M (eds.) Handbook of Nanosafety. Measurement, Exposure and Toxicology – January 2014
• Berges MGM, Aitken RJ, Peters S, Savolainen K, Luo tamo M, Brock Tm- Risk assessment and risk management – Vogel U, Savolainen K, Wu Q, van Tongeren M, Brouwer D, Berges M (eds.) Handbook of Nanosafety. Measurement, Exposure and Toxicology =- January 2014
• Savolainen K – Future outlook of engineered nanomaterials and nanotechnologies – Vogel U, Savolainen K, Wu Q, van Tongeren M, Brouwer D, Berges M (eds.) Handbook of Nanosafety. Measurement, Exposure and Toxicology – January 2014
• Bergamaschi E, Gulumian M, Kanno J, Savolainen K – Engineered nanomaterials: Biomarkers of exposure and effect – R. Gupta (Ed): Biomarkers in Toxicology – February 2014
• Hougaard KS, Campagnolo L, Fadeel B, Gulumian M, Kagan VE, Möller P, Jacobsen NR, Savolainen K – Developmental toxicity of engineered nanoparticles – Gupta RC (ed.). Reproductive and Developmental Toxicology 2nd ed.