Timeline Progress

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WP7 – Cross species models

Richard Handy A fundamental part of developing a classification system for nanomaterial safety is to identify the toxic effects that different ENMs have across a wide range of organisms, from microbes to mammals, and on different body systems. These effects are assessed by their overall magnitude of toxicity ¬– low toxicity, toxic, very toxic -

November 16th, 2014|Timeline Progress|

WP6 – Cell models

Bengt Fadeel and Lucian Farcal WP6 works on the application of in vitro methods for the assessment of nanomaterial (NM) immunotoxicity and genotoxicity. The hypothesis is that refined in vitro assays can replace in vivo testing of NMs. To achieve this goal, WP6 partners selected and refined the SOPs for the in vitro methods to

November 16th, 2014|Timeline Progress|

WP5 – ENM bio-nanointeraction in biological media

Marco Monopoli The overall objective of WP5 is to clarify the ‘biological identity’ of ENMs before and after they have entered into cells or organisms so that the relationship between the ENM surface (biomolecule corona composition) and mechanisms of toxicity (identified in WP7-10) can be understood. As soon as nanomaterials enter complex environments, such as

November 16th, 2014|Timeline Progress|

WP4 – Life-cycle analysis

Socorro Vázquez-Campos WP4 is devoted to studying the transformation and release of engineered nanomaterials (ENMs) along their life cycle (production, manufacturing, use and disposal) when used in existing applications or industrial processes, and the assessment of the environmental and health impacts of these releases. Researchers have so far performed a selection of representative applications incorporating

November 16th, 2014|Timeline Progress|

WP3 – Materials

Erik Larsen and Manuel Correia The first half of 2014 consisted of finishing the synthesis of the engineered nanomaterials (ENMs), which has now been completed. Present work, which is ongoing, involves the basic characterisation and development of dispersion protocols for the powder materials. Up until now, more than half of the ENMs have been characterised

November 16th, 2014|Timeline Progress|